Structure-based design of a novel synthetic spiroketal pyran as a pharmacophore for the marine natural product spongistatin 1. [electronic resource]
Producer: 20000613Description: 541-5 p. digitalISSN:- 0960-894X
- Animals
- Antineoplastic Agents -- chemical synthesis
- Breast Neoplasms -- pathology
- Crystallography, X-Ray
- Drug Design
- Ethers, Cyclic -- chemistry
- Humans
- Lactones -- chemistry
- Macrolides
- Mitosis -- drug effects
- Models, Molecular
- Nephelometry and Turbidimetry
- Porifera -- chemistry
- Pyrans -- chemical synthesis
- Spiro Compounds -- chemical synthesis
- Structure-Activity Relationship
- Tubulin -- drug effects
- Tumor Cells, Cultured
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Publication Type: Journal Article
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