Midazolam and triazolam biotransformation in mouse and human liver microsomes: relative contribution of CYP3A and CYP2C isoforms. [electronic resource]
Producer: 20000222Description: 618-28 p. digitalISSN:- 0022-3565
- Animals
- Antibodies -- pharmacology
- Aryl Hydrocarbon Hydroxylases
- Biotransformation
- Blotting, Western
- Chromatography, High Pressure Liquid
- Cytochrome P-450 CYP3A
- Cytochrome P-450 Enzyme System -- immunology
- Dose-Response Relationship, Drug
- Humans
- Immunochemistry
- In Vitro Techniques
- Inhibitory Concentration 50
- Ketoconazole -- pharmacology
- Mice
- Microsomes, Liver -- metabolism
- Midazolam -- pharmacokinetics
- Mixed Function Oxygenases -- immunology
- Oxidoreductases, N-Demethylating -- physiology
- Protein Isoforms -- physiology
- Species Specificity
- Steroid 16-alpha-Hydroxylase
- Steroid Hydroxylases -- immunology
- Triazolam -- pharmacokinetics
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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