Down-regulation of the pharmacokinetic-pharmacodynamic response to interleukin-12 during long-term administration to patients with renal cell carcinoma and evaluation of the mechanism of this "adaptive response" in mice. [electronic resource]
Producer: 19990709Description: 615-29 p. digitalISSN:- 0009-9236
- Adjuvants, Immunologic -- administration & dosage
- Adult
- Aged
- Animals
- Carcinoma, Renal Cell -- blood
- Down-Regulation
- Drug Administration Schedule
- Female
- Gene Expression Regulation, Neoplastic
- Humans
- Interferon-gamma -- blood
- Interleukin-12 -- administration & dosage
- Kidney Neoplasms -- blood
- Male
- Mice
- Mice, Inbred C57BL
- Middle Aged
- RNA, Messenger -- analysis
- Recombinant Proteins -- pharmacology
- beta 2-Microglobulin -- metabolism
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Publication Type: Clinical Trial; Clinical Trial, Phase I; Journal Article; Multicenter Study
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